Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.48 |
| ▸ | GRM5 | P41594 | 9/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20760484 | 0.88 | GRM1 (0.60) | GRM1GRM5PDK4NAMPT | |
| SCHEMBL15001430 | 0.88 | GRM1 (0.52) | GRM1GRM5PDK4GPR119BTK | |
| SCHEMBL28884398 | 0.86 | RXFP1 (0.45) | MAPTGRM5NAMPT | |
| SCHEMBL20760680 | 0.84 | GRM1 (0.50) | GRM1GRM5PDK4GPR119NAMPT | |
| SCHEMBL29766150 | 0.84 | GRM1 (0.50) | GRM1GRM5PDK4GPR119NAMPT | |
| SCHEMBL63673 | 0.82 | GRM1 (0.51) | GRM1GRM5PDK4GPR119NAMPT | |
| SCHEMBL64701 | 0.82 | GRM1 (0.55) | GRM1GRM5PDK4GPR119BTK | |
| SCHEMBL15756310 | 0.82 | GRM1 (0.55) | GRM1GRM5PDK4GPR119NAMPT | |
| SCHEMBL8193684 | 0.82 | NAMPT (0.59) | MAPTKDM4EGRM1GRM5PDK4 | |
| SCHEMBL20760865 | 0.81 | GRM1 (0.48) | GRM1GRM5PDK4GPR119NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891953-B | Pyrrolotriazines derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2022-07-12 | — | — | CN | disclosed |
| WO-2019034128-A1 | PYRROLOTRIAZINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 浙江海正药业股份有限公司 | 2019-02-21 | — | — | WO | disclosed |