Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | VNN1 | O95497 | 8/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20760645 | 0.86 | MAPT (0.52) | NAMPTMAPTGRM5 | |
| SCHEMBL28368651 | 0.84 | NPC1 (0.44) | RXFP1VNN1NAMPTLMNANPSR1 | |
| SCHEMBL14562979 | 0.80 | QDPR (0.53) | NAMPTALDH1A1ALOX15TDP1HPGD | |
| SCHEMBL28368267 | 0.79 | VNN1 (0.44) | VNN1ALDH1A1ALOX15HPGDMEN1 | |
| SCHEMBL28364566 | 0.77 | ALDH1A1 (0.36) | NAMPTALDH1A1ALOX15TDP1MEN1 | |
| SCHEMBL28365163 | 0.76 | TRPV1 (0.41) | VNN1LMNAALDH1A1MEN1MAPT | |
| SCHEMBL29766145 | 0.75 | RXFP1 (0.48) | RXFP1VNN1LMNANPSR1ALDH1A1 | |
| SCHEMBL18009528 | 0.74 | ALDH1A1 (0.41) | NAMPTALDH1A1ALOX15HPGDMEN1 | |
| SCHEMBL15952943 | 0.74 | NAMPT (0.47) | NAMPTTDP1MAPK1RAB9AKMT2A | |
| SCHEMBL20760484 | 0.73 | GRM1 (0.60) | NAMPTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891953-B | Pyrrolotriazines derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-110891953-A | Pyrrolotriazines derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2020-03-17 | — | — | CN | disclosed |