Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 17/20 | 0.69 |
| ▸ | ESR1 | P03372 | 6/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20764037 | 0.91 | ESRRG (0.72) | ESRRGESR1ESR2MAPTTP53 | |
| SCHEMBL20764024 | 0.82 | ESRRG (1.00) | ESRRGESR1ESR2MAPTTP53 | |
| SCHEMBL31337285 | 0.82 | ESRRG (1.00) | ESRRGESR1ESR2MAPTTP53 | |
| SCHEMBL20746251 | 0.82 | ESRRG (1.00) | ESRRGESR1ESR2MAPTTP53 | |
| SCHEMBL20764084 | 0.81 | ESRRG (0.74) | ESRRGESR1ESR2RXFP1NPC1 | |
| SCHEMBL20764056 | 0.80 | ESRRG (1.00) | ESRRGESR1ESR2MAPTTP53 | |
| SCHEMBL20764242 | 0.79 | ESRRG (0.74) | ESRRGESR1ESR2MAPTSMN1; SMN2 | |
| SCHEMBL20764093 | 0.79 | ESRRG (0.74) | ESRRGESR1ESR2MAPTSMN1; SMN2 | |
| SCHEMBL20764045 | 0.78 | IDE (0.62) | ESRRGESR1ESR2MAPTTP53 | |
| SCHEMBL20764006 | 0.76 | ESRRG (0.71) | ESRRGESR1ESR2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019036562-A1 | ERR INVERSE AGONISTS | SAINT LOUIS UNIVERSITY (US) | 2019-02-21 | — | — | WO | disclosed |