SCHEMBL20764851

SCHEMBL20764851

OC[CH]c1cccc(Br)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.59
HSD17B3 P37058 1/20 0.50
MAPT P10636 1/20 0.46
SLC6A19 Q695T7 1/20 0.44
BACE1 P56817 1/20 0.44
HSD11B1 P28845 1/20 0.43
PKM P14618 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
MAOA P21397 2/20 0.40
MAOB P27338 2/20 0.40
POLB P06746 1/20 0.39
PLEC Q15149 1/20 0.39
CTDSP1 Q9GZU7 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP1B1 Q16678 1/20 0.39
MAPK1 P28482 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C19 P33261 1/20 0.38
CISD1 Q9NZ45 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28769190 0.80 ALDH1A1 (0.61) ALDH1A1HSD17B3MAPTSLC6A19BACE1
SCHEMBL16618643 0.80 ALDH1A1 (0.61) ALDH1A1HSD17B3MAPTSLC6A19BACE1
SCHEMBL4084843 0.79 HSD17B3 (0.56) ALDH1A1HSD17B3MAPTSLC6A19BACE1
SCHEMBL4084847 0.79 HSD17B3 (0.56) ALDH1A1HSD17B3MAPTSLC6A19BACE1
Ethylene Glycol SCHEMBL28561903 0.79 ALDH1A1 (0.80) ALDH1A1HSD17B3MAPTSLC6A19BACE1
SCHEMBL12479845 0.78 ALDH1A1 (0.59) ALDH1A1HSD17B3MAPTSLC6A19BACE1
SCHEMBL18243744 0.77 ALDH1A1 (0.57) ALDH1A1HSD17B3MAPTSLC6A19BACE1
SCHEMBL933470 0.76 HSD17B3 (0.53) ALDH1A1HSD17B3MAPTSLC6A19BACE1
SCHEMBL28099212 0.76 LCK (0.54) ALDH1A1MAPT
Ethylene Glycol SCHEMBL5831465 0.75 ALDH1A1 (0.50) ALDH1A1HSD17B3MAPTSLC6A19BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3672973-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-07-01 EP claimed
WO-2019037640-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-02-28 WO claimed
EP-3672973-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-07-01 EP disclosed
WO-2019037640-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-02-28 WO disclosed
CN-101522657-B STAT3/5 activation inhibitor OTSUKA PHARMACEUTICAL CO.,LTD. (JP) 2014-10-15 CN disclosed
CN-1993339-B Aromatic compound OTSUKA PHARMA CO LTD 2013-05-22 CN disclosed
CN-101522657-A STAT3/5 activation inhibitor OTSUKA PHARMA CO LTD (JP) 2009-09-02 CN disclosed
CN-1993339-A Aromatic compound OTSUKA PHARMA CO LTD (JP) 2007-07-04 CN disclosed