Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MGMT | P16455 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30439186 | 0.79 | MAPT (0.56) | MAPTCASP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20764961 | 0.79 | MAPT (0.56) | MAPTCASP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20764944 | 0.75 | CA1 (0.39) | MAPTNPC1RAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL2404284 | 0.74 | ALDH1A1 (0.49) | MAPTCASP1NPC1RAB9ACYP1A2 | |
| SCHEMBL28259828 | 0.72 | HPRT1 (0.47) | MAPTHPRT1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL27458439 | 0.69 | ALDH1A1 (0.47) | MAPTHPRT1NPC1RAB9ACYP1A2 | |
| SCHEMBL16937118 | 0.68 | TDP1 (0.55) | MAPTHPRT1RAB9AALDH1A1POLB | |
| SCHEMBL30139580 | 0.68 | TDP1 (0.55) | MAPTHPRT1RAB9AALDH1A1POLB | |
| SCHEMBL30622686 | 0.68 | MEN1 (0.45) | MAPTSMN1; SMN2MGMTALDH1A1L3MBTL1 | |
| SCHEMBL1959760 | 0.68 | MEN1 (0.45) | MAPTSMN1; SMN2MGMTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672951-B1 | QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2023-08-30 | — | — | EP | disclosed |
| CN-110944994-B | Quinoxaline derivatives as adenosine receptor antagonists | 默克专利股份公司 | 2023-06-09 | — | — | CN | disclosed |
| US-11192899-B2 | Quinoxaline derivatives as adenosine receptor antagonists | MERCK PATENT GMBH (DE) | 2021-12-07 | — | — | US | disclosed |
| US-20200354375-A1 | QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2020-11-12 | — | — | US | disclosed |
| EP-3672951-A1 | QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | Merck Patent GmbH (DE) | 2020-07-01 | — | — | EP | disclosed |
| CN-110944994-A | Quinoxaline derivatives as adenosine receptor antagonists | 默克专利股份公司 | 2020-03-31 | — | — | CN | disclosed |
| WO-2019038214-A1 | QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2019-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354375-A1 | QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | ADORA2A, ADORA1, P2RY1 | MAPT 4830/4885CASP1 2352/4885HPRT1 41/4885 |
| US-11192899-B2 | Quinoxaline derivatives as adenosine receptor antagonists | ADORA2A, ADORA1, P2RY1 | MAPT 4830/4885CASP1 2352/4885HPRT1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.