Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.71 |
| ▸ | GHSR | Q92847 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ME2 | P23368 | 1/20 | 0.47 |
| ▸ | ME1 | P48163 | 1/20 | 0.47 |
| ▸ | ME3 | Q16798 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6095301 | 0.86 | MAPK14 (0.79) | MAPK14GHSRNPC1KDM4EALDH1A1 | |
| SCHEMBL20765535 | 0.81 | KDM4E (0.57) | MAPK14NPC1TDP1KDM4EPOLB | |
| SCHEMBL20765688 | 0.81 | GHSR (0.65) | MAPK14GHSRNPC1POLBSMN1; SMN2 | |
| SCHEMBL20765500 | 0.81 | MAPK14 (0.70) | MAPK14GHSRNPC1KDM4EMAPK1 | |
| SCHEMBL14028477 | 0.80 | GHSR (1.00) | MAPK14GHSRMAPK1HPGD | |
| SCHEMBL17443852 | 0.80 | GHSR (0.75) | MAPK14GHSRKDM4EALDH1A1HPGD | |
| SCHEMBL6093708 | 0.78 | MAPK14 (0.79) | MAPK14GHSRNPC1 | |
| SCHEMBL27158221 | 0.77 | MAPK14 (0.65) | MAPK14GHSRKDM4EALDH1A1HPGD | |
| SCHEMBL7131839 | 0.76 | NPC1 (0.86) | NPC1TDP1POLBSMN1; SMN2FKBP1A | |
| SCHEMBL16598935 | 0.76 | GHSR (0.70) | MAPK14GHSRKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | claimed |