Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.57 |
| ▸ | IKZF2 | Q9UKS7 | 11/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.52 |
| ▸ | SALL4 | Q9UJQ4 | 1/20 | 0.49 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21340261 | 0.88 | CRBN (0.52) | CRBNIKZF2CSNK1A1SALL4IKZF1 | |
| SCHEMBL24789380 | 0.86 | CRBN (0.57) | CRBNIKZF2CSNK1A1SALL4IKZF1 | |
| SCHEMBL20766670 | 0.85 | IKZF2 (0.65) | CRBNIKZF2IKZF1 | |
| SCHEMBL20765362 | 0.82 | IKZF1 (0.62) | IKZF2IKZF1 | |
| SCHEMBL30368972 | 0.82 | IKZF1 (0.62) | IKZF2IKZF1 | |
| SCHEMBL31021073 | 0.81 | CRBN (0.60) | CRBNIKZF2 | |
| SCHEMBL20936139 | 0.81 | CRBN (0.60) | CRBNIKZF2 | |
| SCHEMBL20765621 | 0.80 | IKZF2 (0.67) | CRBNIKZF2IKZF1 | |
| Hydrochloric Acid SCHEMBL20774920 | 0.80 | CRBN (0.59) | CRBNIKZF2 | |
| Hydrochloric Acid SCHEMBL30477333 | 0.80 | CRBN (0.59) | CRBNIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672949-A1 | 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019038717-A1 | 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2019-02-28 | — | — | WO | disclosed |