Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 3/20 | 0.37 |
| ▸ | TTR | P02766 | 3/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11622080 | 0.86 | MAOB (0.56) | PSMB5PSMB8MAOBTTRALOX12 | |
| SCHEMBL2094640 | 0.83 | PSMB5 (0.42) | PSMB5PSMB8CYP1A2CYP2A6AHR | |
| SCHEMBL20765731 | 0.83 | PSMB5 (0.42) | PSMB5PSMB8CYP1A2CYP2A6AHR | |
| SCHEMBL7568303 | 0.81 | SMN1; SMN2 (0.55) | PSMB5PSMB8TTRKDM4EMAPT | |
| SCHEMBL10394749 | 0.79 | PSMB5 (0.43) | PSMB5PSMB8CYP1A2CYP2A6AHR | |
| SCHEMBL10394688 | 0.77 | PSMB5 (0.42) | PSMB5PSMB8TTRNR4A2LMNA | |
| SCHEMBL17652414 | 0.77 | PSMB5 (0.46) | PSMB5PSMB8MAOBCYP1A2CYP2A6 | |
| SCHEMBL9843775 | 0.77 | MAOB (0.44) | PSMB5PSMB8MAOBKDM4ESMN1; SMN2 | |
| SCHEMBL17653768 | 0.76 | MAOB (0.43) | PSMB5PSMB8MAOBLMNATP53 | |
| SCHEMBL2091348 | 0.75 | PSMB5 (0.38) | PSMB5PSMB8CYP1A2CYP2A6AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858951-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-11858951-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-11858951-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| CN-111183142-B | Boric acid derivatives | 默克专利股份公司 | 2023-06-16 | — | — | CN | disclosed |
| EP-3672977-B1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2022-06-22 | — | — | EP | disclosed |
| EP-3672977-B1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2022-06-22 | — | — | EP | disclosed |
| US-20220153761-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2022-05-19 | — | — | US | disclosed |
| US-20220153761-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2022-05-19 | — | — | US | disclosed |
| US-11274109-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2022-03-15 | — | — | US | disclosed |
| US-11274109-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2022-03-15 | — | — | US | disclosed |
| US-20200354382-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2020-11-12 | — | — | US | disclosed |
| US-20200354382-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2020-11-12 | — | — | US | disclosed |
| EP-3672977-A1 | BORONIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2020-07-01 | — | — | EP | disclosed |
| CN-111183142-A | Boronic acid derivatives | 默克专利股份公司 | 2020-05-19 | — | — | CN | disclosed |
| WO-2019038250-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-02-28 | — | — | WO | disclosed |
| WO-2019038250-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153761-A1 | Boronic Acid Derivatives | PSMB7, PSMA7, BRD7 | PSMB5 26/4885PSMB8 8/4885MAOB 3165/4885 |
| US-11274109-B2 | Boronic acid derivatives | PSMB7, PSMA7, BRD7 | PSMB5 23/4885PSMB8 8/4885MAOB 3113/4885 |
| US-11858951-B2 | Boronic acid derivatives | PSMB7, PSMA7, BRD7 | PSMB5 26/4885PSMB8 8/4885MAOB 3165/4885 |
| US-20200354382-A1 | Boronic Acid Derivatives | PSMB7, PSMA7, BRD7 | PSMB5 23/4885PSMB8 8/4885MAOB 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.