PSMB7 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL605949	0.54	15/20
SCHEMBL1478606	0.58	12/20
SCHEMBL607010	0.56	12/20
SCHEMBL609327	0.55	12/20
SCHEMBL1478372	0.55	12/20
SCHEMBL607553	0.54	12/20
SCHEMBL606932	0.53	12/20
SCHEMBL608381	0.53	12/20
SCHEMBL1477893	0.53	12/20
SCHEMBL609081	0.52	12/20
SCHEMBL606926	0.52	12/20
SCHEMBL606344	0.51	12/20
SCHEMBL606616	0.51	12/20
SCHEMBL1327404	0.50	12/20
SCHEMBL607035	0.61	11/20
SCHEMBL609733	0.60	11/20
SCHEMBL609324	0.60	11/20
SCHEMBL605158	0.59	11/20
SCHEMBL606315	0.59	11/20
SCHEMBL1477637	0.57	11/20

Clinical trials — most relevant to PSMB7 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease	PHASE4	UNKNOWN
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy	PHASE2	NOT_YET_RECRUITING
Doxorubicin and Bortezomib in Treating Patients With Liver Cancer	PHASE2	COMPLETED
A Study of the Safety and Efficacy of CNTO 328 and Bortezomib to Bortezomib Alone in Patients With Relapsed or Refractory Multiple Myeloma	PHASE2	COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Tamoxifen and Bortezomib to Treat Recurrent Brain Tumors	PHASE2	COMPLETED
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
MLN9708 and Dexamethasone for High-Risk Smoldering Multiple Myeloma	PHASE2	WITHDRAWN
A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma	PHASE2	WITHDRAWN
Colchicine for Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Study of Patients With Stage IV Malignant Melanoma Using PS-341 (Bortezomib, Velcade) and Interferon-alpha-2b in Malignant Melanoma	PHASE1	COMPLETED
Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer	PHASE1	COMPLETED
Study of Irinotecan and Bortezomib in Children With Recurrent/Refractory Neuroblastoma	PHASE1	COMPLETED
GO-203-2C + Bortezomib For Relapsed Or Refractory MM	PHASE1	WITHDRAWN
Extended Infusion Carfilzomib on a Weekly Schedule in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
Cardiovascular Complications of Carfilzomib Treatment	nan	UNKNOWN
Characterization of the Changes in the Signalling Pathways During Spinal Cord Injury-induced Skeletal Muscle Atrophy	nan	UNKNOWN
Evaluation of Proteasome as a Marker of Hepatocellular Carcinoma in Cirrhotic Patients Following Curative Treatment	nan	UNKNOWN
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS)	nan	UNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT)	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
The Pathophysiology of Bortezomib Induced Peripheral Neuropathy	nan	UNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Cholesterol and Statin in Healthy Adults	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Relationship Between Nutritional State and Respiratory Muscle Weakness in Adult Patients With Bronchietasis	nan	UNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PSMB7 binder may also engage these)

Protein	Name	Similarity
P70195	—	1.000	P70195 →
A1XQU1	—	1.000	A1XQU1 →
Q2TBP0	—	1.000	Q2TBP0 →
Q9JHW0	—	1.000	Q9JHW0 →
Q7DLS1	—	1.000	Q7DLS1 →
Q09841	—	1.000	Q09841 →
Q54QR2	—	1.000	Q54QR2 →
O23710	—	0.999	O23710 →
P28064	—	0.995	P28064 →
Q8LD27	—	0.995	Q8LD27 →
P38624	—	0.995	P38624 →
P93395	—	0.994	P93395 →
Q3T112	—	0.993	Q3T112 →
P25043	—	0.993	P25043 →
Q5W416	—	0.992	Q5W416 →
Q4KM35	—	0.992	Q4KM35 →
A7KE01	—	0.992	A7KE01 →
Q0J006	—	0.992	Q0J006 →
Q9Z2U0	—	0.992	Q9Z2U0 →
Q9CWH6	—	0.991	Q9CWH6 →
A7KII6	—	0.991	A7KII6 →
Q3T0T1	—	0.991	Q3T0T1 →
Q54BC8	—	0.991	Q54BC8 →
A2YXU2	—	0.991	A2YXU2 →
PSMB10	Proteasome subunit beta type-10	0.991	landscape →
O55234	—	0.991	O55234 →
O24361	—	0.991	O24361 →
PSMB8	Proteasome subunit beta type-8	0.991	landscape →
O43063	—	0.991	O43063 →
Q3ZBG0	—	0.990	Q3ZBG0 →