Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17824126 | 1.00 | KDM4E (0.37) | KDM4EMAPTTHRBALDH1A1NR1H2 | |
| SCHEMBL19995843 | 0.88 | KDM4E (0.39) | KDM4EMAPTTHRBALDH1A1NR1H2 | |
| SCHEMBL23020680 | 0.82 | MEN1 (0.33) | ALDH1A1ATM | |
| SCHEMBL23528096 | 0.81 | USP2 (0.37) | KDM4EMAPTTHRBNR1H2USP2 | |
| SCHEMBL4503706 | 0.81 | USP2 (0.37) | KDM4EMAPTTHRBNR1H2USP2 | |
| SCHEMBL432224 | 0.80 | SETD7 (0.40) | KDM4EMAPTTHRBNR1H2USP2 | |
| SCHEMBL1197830 | 0.80 | SETD7 (0.40) | KDM4EMAPTTHRBNR1H2USP2 | |
| SCHEMBL1197535 | 0.80 | SETD7 (0.40) | KDM4EMAPTTHRBNR1H2USP2 | |
| SCHEMBL585209 | 0.79 | KDM4E (0.34) | KDM4EMAPTTHRBALDH1A1NR1H2 | |
| SCHEMBL585012 | 0.79 | KDM4E (0.34) | KDM4EMAPTTHRBALDH1A1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040106-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |