Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20766552 | 0.91 | HTR2A (0.53) | HTR2ASLC6A2SLC6A4KDM4EALDH1A1 | |
| SCHEMBL20766382 | 0.89 | HTR2A (0.55) | HTR2ASLC6A2SLC6A4CYP2D6KCNH2 | |
| SCHEMBL20766478 | 0.88 | HTR2A (0.64) | HTR2A | |
| SCHEMBL20766247 | 0.84 | HTR2A (0.62) | HTR2ASLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL20766381 | 0.81 | HTR2A (0.63) | HTR2ASLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL20766219 | 0.80 | HTR2A (0.63) | HTR2A | |
| SCHEMBL20766516 | 0.79 | HTR2A (0.59) | HTR2ASLC6A2SLC6A4CYP2D6KCNH2 | |
| SCHEMBL13003423 | 0.75 | CCR1 (0.47) | MBTPS1HPGD | |
| SCHEMBL20766880 | 0.73 | HTR2A (0.65) | HTR2ASLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL20766347 | 0.73 | ALDH1A1 (0.52) | HTR2ASLC6A2SLC6A4SLC6A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672954-A1 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | Acadia Pharmaceuticals Inc. (US) | 2020-07-01 | — | — | EP | claimed |
| WO-2019040107-A1 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | claimed |
| EP-3672954-A1 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | Acadia Pharmaceuticals Inc. (US) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019040107-A1 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |