SCHEMBL20767196

SCHEMBL20767196

CC(C)Oc1ccc(CN(Cc2ccc(F)cc2)C(=O)CC2CCN(C(=O)OC(C)(C)C)CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 6/20 0.47
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
GPR119 Q8TDV5 7/20 0.45
YAP1 P46937 3/20 0.44
SLC2A1 P11166 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20794805 0.85 HTR2A (0.46) HTR2AMEN1KMT2AGPR119
SCHEMBL20766873 0.81 HTR2A (0.53) HTR2AGPR119
SCHEMBL20767225 0.80 HTR2A (0.54) HTR2A
SCHEMBL27391502 0.79 GPR119 (0.52) GPR119YAP1
SCHEMBL20794679 0.77 HTR2A (0.64) HTR2A
SCHEMBL20767254 0.77 HTR2A (0.56) HTR2A
SCHEMBL20767185 0.77 HTR2A (0.53) HTR2A
SCHEMBL20781013 0.77 HTR2A (0.57) HTR2A
SCHEMBL20767214 0.76 STS (0.53) MEN1KMT2AGPR119SLC2A1
SCHEMBL4773466 0.75 TP53 (0.54) MEN1KMT2AGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019040105-A2 COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES ACADIA PHARMACEUTICALS INC. (US) 2019-02-28 WO disclosed