Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 5/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29109639 | 0.76 | FLT3 (0.50) | FLT3PIK3CAMIFIRAK4PKM | |
| SCHEMBL30566633 | 0.76 | IDO1 (0.48) | IDO1 | |
| SCHEMBL21631035 | 0.76 | IDO1 (0.48) | IDO1 | |
| SCHEMBL20474191 | 0.74 | FLT3 (0.46) | FLT3PIK3CAMIFIRAK4PKM | |
| SCHEMBL31723515 | 0.73 | FLT3 (0.50) | FLT3PIK3CAMIFIRAK4PKM | |
| SCHEMBL13180735 | 0.72 | FLT3 (1.00) | FLT3PIK3CAMIFPKMDYRK1A | |
| SCHEMBL20767014 | 0.72 | MEN1 (0.56) | LIMK1 | |
| SCHEMBL30655418 | 0.72 | FLT3 (0.69) | FLT3PIK3CAMIFIRAK4PKM | |
| SCHEMBL19153658 | 0.72 | FLT3 (0.49) | FLT3PIK3CAMIFIRAK4PKM | |
| SCHEMBL29109646 | 0.72 | FLT3 (0.69) | FLT3PIK3CAMIFIRAK4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672970-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | Gilead Sciences, Inc. (US) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019040102-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2019-02-28 | — | — | WO | disclosed |