Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | KLRK1 | P26718 | 2/20 | 0.41 |
| ▸ | MICA | Q29983 | 2/20 | 0.41 |
| ▸ | RAET1L | Q5VY80 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1643132 | 0.87 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1ROCK2TSHRNPY2R | |
| SCHEMBL2079331 | 0.86 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1ROCK2TRPV1TSHR | |
| SCHEMBL1644164 | 0.85 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1ROCK2TRPV1TSHR | |
| SCHEMBL1642548 | 0.84 | TSHR (0.46) | ALDH1A1L3MBTL1TRPV1TSHR | |
| SCHEMBL2081422 | 0.76 | TSHR (0.49) | ALDH1A1L3MBTL1TSHRMEN1KMT2A | |
| SCHEMBL1643897 | 0.74 | KMT2A (0.40) | ALDH1A1L3MBTL1TSHRKMT2ACES2 | |
| SCHEMBL9846978 | 0.74 | TSHR (0.46) | ALDH1A1L3MBTL1TRPV1TSHR | |
| SCHEMBL1642398 | 0.74 | TSHR (0.44) | ALDH1A1ROCK2TSHRMEN1KMT2A | |
| SCHEMBL1643191 | 0.73 | KDM4E (0.46) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL1642078 | 0.72 | NR3C2 (0.38) | ALDH1A1L3MBTL1TRPV1TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906530-B2 | 1,7-naphthyridine derivatives as p38 MAP kinase inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2011-03-15 | — | — | US | disclosed |
| US-20100227881-A1 | 1,7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227881-A1 | 1,7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | MAPK1, MAPK7, MAPKAPK2 | ALDH1A1 2099/4885L3MBTL1 4231/4885ROCK2 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.