Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.79 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.79 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.79 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.79 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.79 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.79 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.79 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.79 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.79 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.79 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.79 |
| ▸ | PRNP | P04156 | 1/20 | 0.79 |
| ▸ | APP | P05067 | 1/20 | 0.79 |
| ▸ | NQO2 | P16083 | 1/20 | 0.79 |
| ▸ | MTOR | P42345 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29421608 | 1.00 | NR4A2 (0.79) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL15483222 | 0.93 | CHRM2 (0.79) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL30817262 | 0.93 | NR4A2 (0.71) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| Pyrophosphoric Acid SCHEMBL29578167 | 0.90 | KDM4E (0.73) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL14580289 | 0.90 | CHRM2 (0.82) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| Chloroquine SCHEMBL8934 | 0.88 | CHRM2 (1.00) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| Chloroquine SCHEMBL29363614 | 0.88 | CHRM2 (1.00) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| (R)-Chloroquine SCHEMBL29429108 | 0.88 | CHRM2 (1.00) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| (R)-Chloroquine SCHEMBL134500 | 0.88 | CHRM2 (1.00) | NR4A2CHRM2CHRM4CHRM5ADRA2A | |
| Chloroquine SCHEMBL8474661 | 0.88 | CHRM2 (1.00) | NR4A2CHRM2CHRM4CHRM5ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220112625-A1 | Diagnosing and Treating Neurological and Autoimmune Diseases by Optimizing Metabolic Responses | POSTREL RICHARD (US) | 2022-04-14 | — | — | US | claimed |
| US-20190070166-A1 | Optimized Method for Treating and Curing Arthritis, Diabetes, Multiple Sclerosis and Other Autoimmune Disease | POSTREL RICHARD (US) | 2019-03-07 | — | — | US | claimed |
| CN-115232015-A | Synthetic method of chloroquine chiral side chain | 暨明医药科技（苏州）有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-114796520-A | anti-CD 74 antibody conjugates, compositions comprising anti-CD 74 antibody conjugates, and methods of use of anti-CD 74 antibody conjugates | 苏特罗生物制药公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-114746420-A | 1- (4- (aminomethyl) benzyl) -2-butyl-2H-pyrazolo [3,4-c ] quinolin-4-amine derivatives as Toll-like receptor (TLR)7/8 agonists and related compounds and antibody drug conjugates thereof for cancer therapy and diagnosis | 苏特罗生物制药公司 | 2022-07-12 | — | — | CN | disclosed |
| US-20220112625-A1 | Diagnosing and Treating Neurological and Autoimmune Diseases by Optimizing Metabolic Responses | POSTREL RICHARD (US) | 2022-04-14 | — | — | US | disclosed |
| CN-114269749-A | 5H-pyrrolo [3,2-d ] pyrimidine-2, 4-diamino compounds and antibody conjugates thereof | 苏特罗生物制药公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-114206392-A | Immunomodulatory agent antibody drug conjugates and uses thereof | 苏特罗生物制药公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-112313336-A | Method for optimizing antibody expression | AMBRX公司 | 2021-02-02 | — | — | CN | disclosed |
| US-20190070166-A1 | Optimized Method for Treating and Curing Arthritis, Diabetes, Multiple Sclerosis and Other Autoimmune Disease | POSTREL RICHARD (US) | 2019-03-07 | — | — | US | disclosed |