Chloroquine

Chloroquine

SCHEMBL8474661

CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 1.00
CHRM4 P08173 3/20 1.00
CHRM5 P08912 3/20 1.00
ADRA2A P08913 3/20 1.00
CHRM1 P11229 3/20 1.00
ADRA2B P18089 3/20 1.00
ADRA2C P18825 3/20 1.00
CHRM3 P20309 3/20 1.00
KCNH2 Q12809 3/20 1.00
TMEM97 Q5BJF2 2/20 1.00
SIGMAR1 Q99720 2/20 1.00
ACE2 Q9BYF1 2/20 1.00
NR4A2 P43354 2/20 1.00
CYP2D6 P10635 2/20 1.00
PRNP P04156 2/20 1.00
MTOR P42345 2/20 1.00
CYP2C19 P33261 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
APP P05067 1/20 1.00
NQO2 P16083 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chloroquine SCHEMBL8933 1.00 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
(R)-Chloroquine SCHEMBL29429108 1.00 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
(R)-Chloroquine SCHEMBL134500 1.00 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
Chloroquine SCHEMBL29363614 1.00 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
Chloroquine SCHEMBL8934 1.00 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
Chloroquine SCHEMBL23854336 0.99 CHRM2 (0.98) CHRM2CHRM4CHRM5ADRA2ACHRM1
Chloroquine SCHEMBL3302947 0.99 CHRM2 (0.98) CHRM2CHRM4CHRM5ADRA2ACHRM1
Chloroquine SCHEMBL5488804 0.99 CHRM2 (0.98) CHRM2CHRM4CHRM5ADRA2ACHRM1
Chloroquine SCHEMBL9862220 0.99 CHRM2 (0.98) CHRM2CHRM4CHRM5ADRA2ACHRM1
Chloroquine SCHEMBL22534361 0.99 CHRM2 (0.98) CHRM2CHRM4CHRM5ADRA2ACHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015068142-A2 COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS, USES AND METHOD OF MANAGEMENT OF MYELOPROLIFERATIVE DISORDER CELLWORKS GROUP, INC. (US) 2015-05-14 WO disclosed
CN-103191113-A Composition containing chloroquine phosphate TIANJIN JIAFAN BIOLOG TECHNOLOGY CO LTD 2013-07-10 CN disclosed
CN-101980707-A Novel substituted imidazoquinoline compounds 4SC AG 2011-02-23 CN disclosed
EP-0931159-A2 NON-MAMMALIAN DNA VIRUS HAVING AN ALTERED COAT PROTEIN THE GENERAL HOSPITAL CORPORATION (US) 1999-07-28 EP disclosed
WO-1998012311-A2 USE OF A NON-MAMMALIAN DNA VIRUS TO EXPRESS AN EXOGENOUS GENE IN A MAMMALIAN CELL THE GENERAL HOSPITAL CORPORATION (US) 1998-03-26 WO disclosed
US-5731182-A GROWING CELL UNDER CONDITIONS SUCH THAT GENE IS EXPRESSED THE GENERAL HOSPITAL CORPORATION (US) 1998-03-24 US disclosed
WO-1998011243-A2 EXPRESSION OF AN EXOGENOUS GENE IN A MAMMALIAN CELL BY USE OF A NON-MAMMALIAN DNA VIRUS HAVING AN ALTERED COAT PROTEIN THE GENERAL HOSPITAL CORPORATION (US) 1998-03-19 WO disclosed