⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20896665 | 1.00 | — | — | |
| SCHEMBL20606550 | 0.81 | — | — | |
| SCHEMBL19210917 | 0.81 | — | — | |
| SCHEMBL570338 | 0.81 | POLB (0.32) | — | |
| SCHEMBL15104801 | 0.79 | — | — | |
| SCHEMBL5778285 | 0.78 | POLB (0.31) | — | |
| SCHEMBL666525 | 0.78 | POLB (0.31) | — | |
| SCHEMBL20484329 | 0.75 | ALDH1A1 (0.38) | — | |
| SCHEMBL25293911 | 0.75 | — | — | |
| SCHEMBL25283978 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414247-B1 | SPIROINDOLINONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-04-21 | — | — | EP | disclosed |
| US-10618897-B2 | Spiroindolinones as DDR1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2020-04-14 | — | — | US | disclosed |
| US-20190071444-A1 | SPIROINDOLINONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-03-07 | — | — | US | disclosed |