Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpropamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | THRB | P10828 | 1/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.82 |
| ▸ | HTR2A | P28223 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.82 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpropamide SCHEMBL23947 | 0.91 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRCYP3A4THRB | |
| Chlorpropamide SCHEMBL1537108 | 0.91 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRCYP3A4THRB | |
| Chlorpropamide SCHEMBL28353575 | 0.89 | ALDH1A1 (0.97) | ALDH1A1LMNATSHRCYP3A4THRB | |
| Chlorpropamide SCHEMBL6471158 | 0.88 | ALDH1A1 (0.94) | ALDH1A1LMNATSHRCYP3A4THRB | |
| SCHEMBL24075260 | 0.86 | ALDH1A1 (0.75) | ALDH1A1LMNATSHRCYP3A4THRB | |
| Chlorpropamide SCHEMBL6471167 | 0.86 | ALDH1A1 (0.84) | ALDH1A1LMNATSHRCYP3A4THRB | |
| Chlorpropamide SCHEMBL6471173 | 0.86 | ALDH1A1 (0.84) | ALDH1A1LMNATSHRCYP3A4THRB | |
| SCHEMBL2290886 | 0.85 | ALDH1A1 (0.72) | ALDH1A1LMNATSHRCYP3A4THRB | |
| Tolbutamide SCHEMBL12498646 | 0.81 | ALDH1A1 (0.82) | ALDH1A1LMNATSHRCYP3A4THRB | |
| Chlorpropamide SCHEMBL20771094 | 0.80 | ALDH1A1 (0.78) | ALDH1A1LMNATSHRCYP3A4THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046303-A1 | A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-07 | — | — | WO | disclosed |