Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | ADH1B | P00325 | 1/20 | 0.42 |
| ▸ | ADH1C | P00326 | 1/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | ADH4 | P08319 | 1/20 | 0.42 |
| ▸ | ADH7 | P40394 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22493178 | 1.00 | ACE2 (0.45) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL8948125 | 1.00 | ACE2 (0.45) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL29303870 | 1.00 | ACE2 (0.45) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL18591106 | 1.00 | ACE2 (0.45) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL30686660 | 1.00 | ACE2 (0.45) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL27333651 | 1.00 | ACE2 (0.45) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL14307876 | 1.00 | ACE2 (0.45) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL21298785 | 1.00 | ACE2 (0.45) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL13474807 | 0.98 | OPRM1 (0.44) | ACE2EPHX1OPRM1ADH1BADH1C | |
| SCHEMBL13443141 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046126-A1 | AMINOGLYCOSIDES AND USES THEREOF | ACHAOGEN, INC. (US) | 2019-03-07 | — | — | WO | disclosed |