⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4995276 | 1.00 | — | — | |
| SCHEMBL2510153 | 1.00 | — | — | |
| SCHEMBL12205278 | 1.00 | — | — | |
| SCHEMBL2559930 | 0.79 | — | — | |
| SCHEMBL28530476 | 0.74 | — | — | |
| SCHEMBL771974 | 0.73 | — | — | |
| Isopropyl Alcohol SCHEMBL9131852 | 0.73 | ALDH1A1 (0.38) | — | |
| SCHEMBL703096 | 0.73 | — | — | |
| SCHEMBL5417916 | 0.73 | — | — | |
| SCHEMBL19672403 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174273-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-11-16 | — | — | US | disclosed |
| US-20210284656-A9 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2021-09-16 | — | — | US | disclosed |
| US-20190161500-A1 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2019-05-30 | — | — | US | disclosed |
| US-10221194-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-03-05 | — | — | US | disclosed |