Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 7/20 | 0.51 |
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | KIF5B | P33176 | 1/20 | 0.51 |
| ▸ | KRAS | P01116 | 1/20 | 0.48 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1985538 | 0.84 | LCK (0.66) | LCKSRCTRPA1KDREGFR | |
| SCHEMBL3332968 | 0.81 | PIK3CA (0.57) | TRPA1EGFRGAK | |
| SCHEMBL13918286 | 0.80 | ENPP1 (0.67) | LCKSRCKDREGFRKRAS | |
| SCHEMBL12003599 | 0.80 | ENPP1 (0.67) | LCKSRCKDREGFRKRAS | |
| SCHEMBL13906935 | 0.79 | LCK (0.60) | LCKSRCTRPA1KDREGFR | |
| SCHEMBL13757489 | 0.78 | TRPA1 (0.56) | LCKSRCTRPA1EGFRFLT3 | |
| SCHEMBL25671083 | 0.77 | SRC (0.51) | LCKSRCKDREGFRRET | |
| SCHEMBL11316949 | 0.76 | PDE1B (0.58) | LCKSRCKDREGFRRET | |
| SCHEMBL23457663 | 0.73 | LCK (0.74) | LCKTRPA1KDREGFRRET | |
| SCHEMBL28891487 | 0.73 | KIT (0.39) | LCKSRCTRPA1KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046778-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | MAVUPHARMA, INC. (US) | 2019-03-07 | — | — | WO | disclosed |