SCHEMBL20786705

SCHEMBL20786705

C[C@@]12CCC(C3CN[C@@H](O)CN3C(=O)O)CC1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc(=O)oc3)CC[C@]12O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATP1A1 P05023 11/20 0.64
ATP1B1 P05026 11/20 0.64
ATP1A3 P13637 11/20 0.64
ATP1B2 P14415 11/20 0.64
ATP1A2 P50993 11/20 0.64
ATP1B3 P54709 11/20 0.64
FXYD2 P54710 11/20 0.64
ATP1A4 Q13733 11/20 0.64
CYP3A4 P08684 3/20 0.64
CYP3A5 P20815 2/20 0.64
AR P10275 1/20 0.64
ZFP91 Q96JP5 1/20 0.64
CYP3A7 P24462 1/20 0.56
STAT3 P40763 1/20 0.48
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
PAX8 Q06710 2/20 0.43
LMNA P02545 2/20 0.43
TP53 P04637 2/20 0.43
TSHR P16473 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20786731 0.94 ATP1A1 (0.64) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL20786722 0.88 ATP1A1 (0.65) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL714900 0.88 ATP1A1 (0.63) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL714902 0.88 ATP1A1 (0.63) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL20786727 0.85 ATP1A1 (0.64) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL18662192 0.82 ATP1A1 (0.64) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL714901 0.82 ATP1A1 (0.63) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL20786724 0.81 ATP1A1 (0.68) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL20786718 0.79 ATP1A1 (0.66) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL22769567 0.79 ATP1A1 (0.64) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3453714-A2 CARDENOLIDE AND BUFADIENOLIDE 3-CARBONATE AND 3-CARBAMATE DERIVATIVES FOR THE TREATMENT OF CANCER AND COMPOSITIONS THEREOF Suzhou Neupharma Co., Ltd (CN) 2019-03-13 EP disclosed