Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 3/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 7/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20809224 | 0.84 | GRM2 (0.41) | GRM2HTR2AHTR2CHSP90AB1TNF | |
| SCHEMBL6923560 | 0.82 | GRM2 (0.55) | PSMB1PSMB5GRM2HTR2AHTR2C | |
| SCHEMBL21025688 | 0.81 | NR1I2 (0.39) | GRM2HSP90AB1TNFHTR2B | |
| SCHEMBL20786928 | 0.80 | HDAC3 (0.47) | PSMB1PSMB5GRM2HTR2AHTR2C | |
| SCHEMBL20809182 | 0.80 | PSMB1 (0.41) | PSMB1PSMB5GRM2HTR2AHTR2C | |
| SCHEMBL20808710 | 0.80 | PSMB1 (0.41) | PSMB1PSMB5GRM2HTR2AHTR2C | |
| SCHEMBL18151616 | 0.79 | — | — | |
| SCHEMBL1500208 | 0.79 | PSMB1 (0.43) | PSMB1PSMB5GRM2HTR2AHTR2C | |
| SCHEMBL20809186 | 0.79 | TNF (0.40) | PSMB1PSMB5GRM2HTR2AHTR2C | |
| SCHEMBL20786912 | 0.79 | HSD17B10 (0.42) | PSMB1PSMB5GRM2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3453707-B1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2022-02-16 | — | — | EP | disclosed |
| CN-107344931-B | Benzazepine derivative, preparation method thereof, pharmaceutical composition and application thereof | 上海迪诺医药科技有限公司 | 2020-09-15 | — | — | CN | disclosed |
| EP-3453707-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2019-03-13 | — | — | EP | disclosed |