Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.46 |
| ▸ | JUN | P05412 | 4/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16514311 | 0.85 | EGFR (0.62) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL16513586 | 0.80 | EGFR (0.59) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL29848021 | 0.80 | EGFR (0.59) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL16513865 | 0.77 | MAPK10 (0.64) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL29847770 | 0.76 | JAK2 (0.56) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL16514398 | 0.76 | JAK2 (0.56) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL29576058 | 0.75 | JAK2 (0.63) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL16823053 | 0.75 | JAK2 (0.63) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL29847699 | 0.74 | JAK2 (0.62) | JAK2BRD4EGFRFGFR2MAPK10 | |
| SCHEMBL16514118 | 0.74 | JAK2 (0.62) | JAK2BRD4EGFRFGFR2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035936-B1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA INC (US) | 2019-03-13 | — | — | EP | disclosed |