Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20788018 | 0.84 | NPC1 (0.69) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20787910 | 0.80 | NPC1 (1.00) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20788014 | 0.78 | NPC1 (0.68) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20787903 | 0.75 | NPC1 (0.74) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20791869 | 0.75 | NPC1 (0.65) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20791859 | 0.75 | NPC1 (0.76) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20788012 | 0.74 | NPC1 (0.63) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20791871 | 0.73 | NPC1 (0.63) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20787900 | 0.73 | NPC1 (0.63) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20791856 | 0.72 | NPC1 (0.70) | NPC1RAB9AKDM4ENPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |