Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20791871 | 0.84 | NPC1 (0.63) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20769725 | 0.82 | RAB9A (0.65) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20787910 | 0.79 | NPC1 (1.00) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL12296355 | 0.76 | NPC1 (1.00) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20788014 | 0.75 | NPC1 (0.68) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20769658 | 0.74 | RAB9A (0.60) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20787900 | 0.74 | NPC1 (0.63) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20787903 | 0.74 | NPC1 (0.74) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL20791859 | 0.74 | NPC1 (0.76) | NPC1RAB9AKDM4ENPSR1LMNA | |
| SCHEMBL22728466 | 0.74 | NPC1 (0.66) | NPC1RAB9AKDM4ENPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |