Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2080874 | 0.90 | HSP90AA1 (0.45) | HSP90AA1NR3C2ALDH1A1HPGDTP53 | |
| SCHEMBL1216693 | 0.90 | HSP90AA1 (0.49) | HSP90AA1NR3C2ALDH1A1HPGDMAPK14 | |
| SCHEMBL1219555 | 0.90 | HSP90AA1 (0.52) | HSP90AA1NR3C2POLBHSP90AB1ALDH1A1 | |
| SCHEMBL1219568 | 0.88 | HSP90AA1 (0.51) | HSP90AA1NR3C2POLBHSP90AB1ALDH1A1 | |
| SCHEMBL2080651 | 0.88 | HSP90AA1 (0.51) | HSP90AA1NR3C2POLBHSP90AB1ALDH1A1 | |
| SCHEMBL1219038 | 0.86 | HSP90AA1 (0.49) | HSP90AA1NR3C2POLBHSP90AB1ALDH1A1 | |
| SCHEMBL1218354 | 0.86 | HSP90AA1 (0.49) | HSP90AA1NR3C2POLBHSP90AB1 | |
| SCHEMBL2079076 | 0.86 | HSP90AA1 (0.49) | HSP90AA1NR3C2POLBHSP90AB1ALDH1A1 | |
| SCHEMBL1219650 | 0.85 | HSP90AA1 (0.48) | HSP90AA1NR3C2POLBHSP90AB1ALDH1A1 | |
| SCHEMBL1219298 | 0.85 | HSP90AA1 (0.48) | HSP90AA1NR3C2POLBHSP90AB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906657-B2 | 1,5-diphenylpyrazoles II as HSP90 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2011-03-15 | — | — | US | claimed |
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2009-12-31 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885NR3C2 570/4885POLB 3152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.