Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.30 |
| ▸ | WEE1 | P30291 | 1/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2080170 | 0.92 | HSP90AA1 (0.43) | HSP90AA1NR3C2SMN1; SMN2ADRA1DF10 | |
| SCHEMBL1217125 | 0.83 | HSP90AA1 (0.45) | HSP90AA1NR3C2PDE11AADRA1DPOLB | |
| SCHEMBL1215330 | 0.77 | HSP90AA1 (0.56) | HSP90AA1NR3C2PDE11A | |
| SCHEMBL15049727 | 0.77 | HSP90AA1 (0.53) | HSP90AA1NR3C2PDE11A | |
| SCHEMBL1219162 | 0.76 | HSP90AA1 (0.49) | HSP90AA1NR3C2SMN1; SMN2ADRA1DPOLB | |
| SCHEMBL1631609 | 0.75 | HSP90AA1 (0.55) | HSP90AA1NR3C2PDE11ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1215976 | 0.75 | HSP90AA1 (0.45) | HSP90AA1NR3C2PDE11AMAPTADRA1D | |
| SCHEMBL1630205 | 0.74 | HSP90AA1 (0.50) | HSP90AA1NR3C2MAPTALDH1A1 | |
| SCHEMBL1629899 | 0.73 | HSP90AA1 (0.48) | HSP90AA1NR3C2ALDH1A1 | |
| SCHEMBL1629182 | 0.71 | HSP90AA1 (0.49) | HSP90AA1NR3C2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906657-B2 | 1,5-diphenylpyrazoles II as HSP90 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2011-03-15 | — | — | US | disclosed |
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885NR3C2 570/4885PDE11A 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.