Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | RRM1 | P23921 | 3/20 | 0.32 |
| ▸ | RRM2B | Q7LG56 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2079362 | 0.92 | HSP90AA1 (0.46) | HSP90AA1NR3C2PRMT5WDR77ALDH1A1 | |
| SCHEMBL1219162 | 0.84 | HSP90AA1 (0.49) | HSP90AA1NR3C2SCN9AALDH1A1HPGD | |
| SCHEMBL1629284 | 0.78 | HSP90AA1 (0.52) | HSP90AA1NR3C2ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1218780 | 0.78 | HSP90AA1 (0.66) | HSP90AA1NR3C2 | |
| SCHEMBL1217125 | 0.77 | HSP90AA1 (0.45) | HSP90AA1NR3C2ALDH1A1ADRA1D | |
| SCHEMBL1628925 | 0.76 | HSP90AA1 (0.47) | HSP90AA1NR3C2SMN1; SMN2 | |
| SCHEMBL1215976 | 0.76 | HSP90AA1 (0.45) | HSP90AA1NR3C2CHRM2CHRM1RRM1 | |
| SCHEMBL1630527 | 0.74 | HSP90AA1 (0.52) | HSP90AA1NR3C2ALDH1A1HPGDF10 | |
| SCHEMBL1628838 | 0.73 | HSP90AA1 (0.47) | HSP90AA1NR3C2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1219128 | 0.73 | HSP90AA1 (0.46) | HSP90AA1NR3C2ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906657-B2 | 1,5-diphenylpyrazoles II as HSP90 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2011-03-15 | — | — | US | disclosed |
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885NR3C2 570/4885SCN9A 3301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.