Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 19/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 19/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 19/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 19/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 19/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 19/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 19/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 19/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 19/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 19/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18373084 | 0.89 | HDAC8 (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18373098 | 0.89 | HDAC8 (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18373085 | 0.88 | HDAC8 (0.60) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL24276656 | 0.87 | HDAC3 (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18356849 | 0.83 | HDAC8 (0.57) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18356650 | 0.83 | HDAC8 (0.57) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18356775 | 0.82 | HDAC8 (0.55) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19851582 | 0.80 | HDAC8 (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL24276602 | 0.78 | EP300 (0.42) | HDAC1 | |
| SCHEMBL24276658 | 0.78 | EPHX2 (0.46) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227352-B2 | Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2019-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227352-B2 | Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity | GBA1, GBA2, GBA3 | HDAC3 1821/4885HDAC4 1637/4885HDAC1 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.