Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 11/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | PEPD | P12955 | 1/20 | 0.31 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165476 | 0.83 | DPP4 (0.39) | RIPK1DPP4DPP8DPP9TSHR | |
| SCHEMBL15099990 | 0.83 | DPP4 (0.39) | RIPK1DPP4DPP8DPP9TSHR | |
| SCHEMBL3664998 | 0.81 | DPP4 (0.41) | RIPK1DPP4DPP8DPP9TSHR | |
| SCHEMBL17711269 | 0.81 | MAPT (0.33) | RIPK1TSHRMAPTGAA | |
| SCHEMBL20820011 | 0.78 | — | — | |
| SCHEMBL20820009 | 0.78 | — | — | |
| SCHEMBL17225490 | 0.78 | DPP4 (0.46) | RIPK1DPP4DPP8DPP9SMN1; SMN2 | |
| SCHEMBL20221847 | 0.78 | DPP4 (0.38) | RIPK1DPP4DPP8DPP9FAP | |
| SCHEMBL7889534 | 0.76 | SMN1; SMN2 (0.39) | RIPK1DPP4DPP8DPP9SMN1; SMN2 | |
| SCHEMBL29942458 | 0.76 | TSHR (0.54) | TSHRMAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |