Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.40 |
| ▸ | PEPD | P12955 | 1/20 | 0.37 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 3/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12747463 | 0.82 | DPP4 (0.42) | DPP4DPP8DPP9PIK3CDPEPD | |
| SCHEMBL318016 | 0.81 | — | — | |
| SCHEMBL19710594 | 0.80 | PIK3CD (0.47) | DPP4DPP8DPP9PIK3CDCHRNB2 | |
| SCHEMBL19508422 | 0.79 | PIK3CD (0.66) | DPP4DPP8DPP9PIK3CDCHRNB2 | |
| SCHEMBL10940585 | 0.79 | SMN1; SMN2 (0.54) | DPP4DPP8DPP9PIK3CDCHRNB2 | |
| SCHEMBL16750118 | 0.78 | PIK3CD (0.65) | DPP4DPP8DPP9PIK3CDCHRNB2 | |
| SCHEMBL21075770 | 0.78 | DPP4 (0.44) | DPP4DPP8DPP9PIK3CDCHRNB2 | |
| SCHEMBL20798666 | 0.78 | RIPK1 (0.40) | DPP4DPP8DPP9PEPDXPNPEP1 | |
| SCHEMBL13165476 | 0.78 | DPP4 (0.39) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| SCHEMBL15099990 | 0.78 | DPP4 (0.39) | DPP4DPP8DPP9CHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9770518-B1 | Anti-DLL3 antibody drug conjugates | ABBVIE STEMCENTRX LLC (US) | 2017-09-26 | — | — | US | disclosed |
| US-9173959-B1 | Anti-DLL3 antibody drug conjugates | STEMCENTRX, INC. (US) | 2015-11-03 | — | — | US | disclosed |