Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.48 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 5/20 | 0.46 |
| ▸ | ACACA | Q13085 | 3/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25080814 | 0.90 | NAMPT (0.53) | KMT2AL3MBTL1DRD2NAMPTNPFFR1 | |
| SCHEMBL4640529 | 0.88 | NPFFR1 (0.51) | KMT2AL3MBTL1DRD2NAMPTNPFFR1 | |
| SCHEMBL4642395 | 0.88 | NPFFR1 (0.51) | KMT2AL3MBTL1DRD2NAMPTNPFFR1 | |
| SCHEMBL4642388 | 0.88 | NPFFR1 (0.51) | KMT2AL3MBTL1DRD2NAMPTNPFFR1 | |
| SCHEMBL14432029 | 0.84 | DRD2 (0.56) | DRD2ACACBACACACKS1BSKP1 | |
| SCHEMBL5450728 | 0.84 | DRD2 (0.56) | DRD2ACACBACACACKS1BSKP1 | |
| SCHEMBL3289146 | 0.84 | DRD2 (0.56) | DRD2ACACBACACACKS1BSKP1 | |
| SCHEMBL8222010 | 0.83 | NPFFR1 (0.49) | KMT2AL3MBTL1DRD2NAMPTNPFFR1 | |
| SCHEMBL3052457 | 0.83 | HDAC3 (0.59) | DRD2CKS1BSKP1SKP2 | |
| SCHEMBL31165348 | 0.83 | NPFFR1 (0.49) | KMT2AL3MBTL1DRD2NAMPTNPFFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10435389-B2 | Octahydrocyclopenta[c]pyrrole allosteric inhibitors of SHP2 | Krouzon Pharmaccuticals, Inc. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190077792-A1 | Octahydrocyclopenta[c]pyrrole Allosteric Inhibitors of SHP2 | Krouzon Pharmaceuticals, Inc. | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077792-A1 | Octahydrocyclopenta[c]pyrrole Allosteric Inhibitors of SHP2 | PTPN1, PTPN2, PTPN7 | KMT2A 1077/4885L3MBTL1 3959/4885DRD2 4732/4885 |
| US-10435389-B2 | Octahydrocyclopenta[c]pyrrole allosteric inhibitors of SHP2 | PTPN1, PTPN2, PTPN7 | KMT2A 1077/4885L3MBTL1 3959/4885DRD2 4732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.