Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20799678 | 0.82 | NPC1 (0.42) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL19146641 | 0.79 | SMN1; SMN2 (0.42) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL20799656 | 0.78 | HPGD (0.41) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL20799682 | 0.77 | HRH4 (0.39) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL23952237 | 0.75 | SMN1; SMN2 (0.55) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL21581187 | 0.75 | SMN1; SMN2 (0.42) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL20799674 | 0.75 | PRCP (0.35) | SMN1; SMN2MMP1MMP3MMP7KDM4E | |
| SCHEMBL20559809 | 0.74 | LPAR2 (0.39) | ALDH1A1HTTSMN1; SMN2KDM4EMAPT | |
| SCHEMBL20558836 | 0.74 | LPAR2 (0.39) | ALDH1A1HTTSMN1; SMN2KDM4EMAPT | |
| SCHEMBL20558839 | 0.74 | LPAR2 (0.39) | ALDH1A1HTTSMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190077767-A1 | VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL BLOCKER | NIPPON CHEMIPHAR CO., LTD. (JP) | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077767-A1 | VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL BLOCKER | CACNA1I, CACNA1G, CACNA1E | ALDH1A1 3220/4885NPC1 3072/4885HTT 2373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.