Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1687229 | 0.83 | PIK3CD (0.42) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL23696591 | 0.82 | GRIN2D (0.38) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL25700789 | 0.82 | HRH3 (0.37) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL23806393 | 0.82 | HRH3 (0.37) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL11911619 | 0.81 | RBP1 (0.38) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL25728347 | 0.81 | GRIN2D (0.34) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL8326704 | 0.81 | SIGMAR1 (0.47) | SIGMAR1HRH3MEN1KMT2A | |
| SCHEMBL13901259 | 0.81 | SLC18A3 (0.34) | KCNH2CACNA1ISLC18A3EPHX2MEN1 | |
| SCHEMBL13225814 | 0.80 | GRIN2D (0.33) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL22856535 | 0.80 | GRIN2D (0.33) | GRIN2DGRIN3BADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3453709-A1 | TETRAHYDROPYRIDOPYRAZINES MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2019-03-13 | — | — | EP | disclosed |