Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20801960 | 1.00 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL22204489 | 1.00 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL24471358 | 0.95 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL24471374 | 0.95 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL24471406 | 0.95 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL25048767 | 0.90 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7053063 | 0.84 | HTR2C (0.54) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL19010044 | 0.83 | ALDH1A1 (0.51) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL716437 | 0.83 | ALDH1A1 (0.51) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL25047797 | 0.80 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11976058-B2 | Aromatic derivatives, preparation methods, and medical uses thereof | BIOARDIS LLC (US) | 2024-05-07 | — | — | US | disclosed |
| CN-110997637-B | Aromatic derivative, preparation method and application thereof in medicine | 保仕健生物科技(上海)有限公司 | 2022-09-27 | — | — | CN | disclosed |
| US-20220169634-A1 | AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF | BIOARDIS LLC | 2022-06-02 | — | — | US | disclosed |
| US-11279697-B2 | Aromatic derivative, preparation method for same, and medical applications thereof | BIOARDIS LLC (US) | 2022-03-22 | — | — | US | disclosed |
| CN-111902400-A | Aromatic derivatives, process for their preparation and their medical use | 保仕健生物科技(上海)有限公司 | 2020-11-06 | — | — | CN | disclosed |
| US-20200262827-A1 | AROMATIC DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF | BIOARDIS LLC (US) | 2020-08-20 | — | — | US | disclosed |
| US-20200262827-A1 | AROMATIC DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF | BIOARDIS LLC (US) | 2020-08-20 | — | — | US | disclosed |
| EP-3680236-A1 | AROMATIC DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF | Bioardis LLC (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3680236-A1 | AROMATIC DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF | Bioardis LLC (US) | 2020-07-15 | — | — | EP | disclosed |
| CN-110997637-A | Aromatic derivative, preparation method and application thereof in medicine | 博奥阿迪斯生物科技公司 | 2020-04-10 | — | — | CN | disclosed |
| WO-2019047826-A1 | AROMATIC DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF | 博奥阿迪斯生物科技公司 | 2019-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11976058-B2 | Aromatic derivatives, preparation methods, and medical uses thereof | FGFR4, FGFR3, FGFR1 | PDE4A 1127/4885PDE4B 916/4885PDE4C 2221/4885 |
| US-11279697-B2 | Aromatic derivative, preparation method for same, and medical applications thereof | FGFR4, FGFR1, FGFR3 | PDE4A 1083/4885PDE4B 671/4885PDE4C 2250/4885 |
| US-20220169634-A1 | AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF | FGFR4, FGFR3, FGFR1 | PDE4A 1127/4885PDE4B 916/4885PDE4C 2221/4885 |
| US-20200262827-A1 | AROMATIC DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF | FGFR4, FGFR1, FGFR3 | PDE4A 1083/4885PDE4B 671/4885PDE4C 2250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.