Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.72 |
| ▸ | ABL2 | P42684 | 1/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.68 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.68 |
| ▸ | AXL | P30530 | 1/20 | 0.65 |
| ▸ | RAF1 | P04049 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 1/20 | 0.64 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2080376 | 0.88 | ABL1 (0.79) | ABL1MAPK14ABL2MAPK8MAPK11 | |
| SCHEMBL2616952 | 0.88 | MAPK14 (0.80) | ABL1MAPK14ABL2MAPK8MAPK11 | |
| SCHEMBL5062231 | 0.88 | ABL1 (0.78) | ABL1MAPK14ABL2MAPK8MAPK11 | |
| SCHEMBL2082325 | 0.86 | ABL1 (0.75) | ABL1MAPK14ABL2MAPK8MAPK11 | |
| SCHEMBL2083222 | 0.84 | ABL1 (0.79) | ABL1MAPK14MAPK11AXLBRAF | |
| SCHEMBL5062052 | 0.84 | ABL1 (0.72) | ABL1MAPK14ABL2MAPK8MAPK11 | |
| SCHEMBL5743898 | 0.84 | MAPK14 (1.00) | ABL1MAPK14ABL2MAPK8MAPK11 | |
| SCHEMBL2079924 | 0.84 | ABL1 (0.72) | ABL1MAPK14ABL2MAPK8MAPK11 | |
| SCHEMBL2083920 | 0.83 | ABL1 (0.80) | ABL1MAPK14MAPK11AXLSRC | |
| SCHEMBL2616949 | 0.83 | MAPK14 (1.00) | ABL1MAPK14ABL2MAPK8MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
| EP-1835934-A2 | ENZYME MODULATORS AND TREATMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | claimed |
| US-20070078121-A1 | Enzyme modulators and treatments | DECIPHERA PHARMACEUTICALS, LLC | 2007-04-05 | — | — | US | claimed |
| WO-2006071940-A2 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-07-06 | — | — | WO | claimed |
| US-8163756-B2 | For example,1-(3-t-butyl-1- (1,2,3,4-tetrahydro- isoquinolin-6-yl)-1H- pyrazol-5-yl)-3-(3- cyanophenyl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163756-B2 | For example,1-(3-t-butyl-1- (1,2,3,4-tetrahydro- isoquinolin-6-yl)-1H- pyrazol-5-yl)-3-(3- cyanophenyl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | disclosed |
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | disclosed |
| US-20070078121-A1 | Enzyme modulators and treatments | DECIPHERA PHARMACEUTICALS, LLC | 2007-04-05 | — | — | US | disclosed |
| US-20070078121-A1 | Enzyme modulators and treatments | DECIPHERA PHARMACEUTICALS, LLC | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078121-A1 | Enzyme modulators and treatments | ABL1, ABL2, LCK | ABL1 1/4885MAPK14 128/4885ABL2 2/4885 |
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | ABL1 20/4885MAPK14 100/4885ABL2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.