Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207210 | 0.84 | PDE7A (0.41) | HSD11B1ITGB3ITGA2BPDE1APDE1B | |
| SCHEMBL208998 | 0.83 | HSD11B1 (0.45) | HSD11B1ITGB3ITGA2B | |
| SCHEMBL208204 | 0.83 | PDE4D (0.49) | HSD11B1PDE1APDE1BPDE4DPDE7A | |
| SCHEMBL208714 | 0.81 | HSD11B1 (0.41) | HSD11B1ITGB3ITGA2BPDE7A | |
| SCHEMBL209306 | 0.81 | HSD11B1 (0.51) | HSD11B1PDE1APDE1BPDE4DPDE7A | |
| SCHEMBL208781 | 0.81 | HSD11B1 (0.43) | HSD11B1ITGB3ITGA2B | |
| SCHEMBL15216431 | 0.81 | HSD11B1 (0.44) | HSD11B1ITGB3ITGA2B | |
| SCHEMBL2721694 | 0.80 | HSD11B1 (0.40) | HSD11B1ITGB3ITGA2B | |
| SCHEMBL15204476 | 0.80 | HSD11B1 (0.40) | HSD11B1ITGB3ITGA2B | |
| SCHEMBL209754 | 0.80 | HSD11B1 (0.45) | HSD11B1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088776-B2 | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-01-03 | — | — | US | claimed |
| US-8088776-B2 | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-01-03 | — | — | US | disclosed |