Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20804312 | 0.87 | AXL (0.46) | RETMAP2K4GPR119TTK | |
| SCHEMBL24148625 | 0.82 | AXL (0.46) | RETMAP2K4GPR119USP30GSK3B | |
| SCHEMBL29746390 | 0.78 | TTK (0.42) | RETMAP2K4GPR119GSK3BDYRK1A | |
| SCHEMBL19950249 | 0.78 | TTK (0.42) | RETMAP2K4GPR119GSK3BDYRK1A | |
| SCHEMBL31393238 | 0.77 | KMT2A (0.41) | MAP2K4MEN1KMT2AL3MBTL1ELANE | |
| SCHEMBL29907124 | 0.77 | TTK (0.40) | RETACVR2ATGFBR2ERN1GPR119 | |
| SCHEMBL23210931 | 0.77 | TTK (0.40) | RETACVR2ATGFBR2ERN1GPR119 | |
| SCHEMBL20791779 | 0.77 | RET (0.42) | RETTTK | |
| SCHEMBL19950686 | 0.75 | MAP4K1 (0.44) | RETMAP2K4TTK | |
| SCHEMBL29746578 | 0.75 | MAP4K1 (0.44) | RETMAP2K4TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019051199-A1 | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS | INCYTE CORPORATION (US) | 2019-03-14 | — | — | WO | disclosed |