Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 12/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 4/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20804310 | 0.87 | RET (0.42) | TTKMAP2K4RETGPR119 | |
| SCHEMBL20791779 | 0.85 | RET (0.42) | TTKRET | |
| SCHEMBL20791817 | 0.85 | AXL (0.51) | AXLCREBBP | |
| SCHEMBL24148625 | 0.83 | AXL (0.46) | AXLTTKCCNA2CDK2AURKA | |
| SCHEMBL19950249 | 0.83 | TTK (0.42) | TTKCCNA2CDK2AURKAMAP2K4 | |
| SCHEMBL29746390 | 0.83 | TTK (0.42) | TTKCCNA2CDK2AURKAMAP2K4 | |
| SCHEMBL23263988 | 0.81 | TTK (0.42) | AXLTTKCCNA2CDK2AURKA | |
| SCHEMBL20804451 | 0.78 | FAAH (0.35) | CDK2AURKAMAP2K4 | |
| SCHEMBL20804449 | 0.77 | FAAH (0.34) | MAP2K4 | |
| SCHEMBL26632174 | 0.76 | TTK (0.41) | TTKCCNA2CDK2AURKARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019051199-A1 | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS | INCYTE CORPORATION (US) | 2019-03-14 | — | — | WO | disclosed |