Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20330502 | 0.92 | GRIN2B (0.37) | GRIN2BGRIN2CCTSKCYP4F2CYP4A11 | |
| SCHEMBL441772 | 0.87 | GRIN2B (0.37) | GRIN2BGRIN2CCTSKCYP4F2CYP4A11 | |
| SCHEMBL444540 | 0.84 | GRIN2B (0.38) | GRIN2BGRIN2CCTSKCYP4F2CYP4A11 | |
| SCHEMBL28498279 | 0.82 | JAK3 (0.35) | GRIN2BGRIN2CCTSKCYP4F2CYP4A11 | |
| SCHEMBL27092776 | 0.81 | GRIN2B (0.39) | GRIN2BGRIN2CCTSKJAK3CNR2 | |
| SCHEMBL21182552 | 0.81 | GRIN2B (0.36) | GRIN2BGRIN2CCTSKCYP4F2CYP4A11 | |
| SCHEMBL443404 | 0.80 | CTSK (0.35) | GRIN2BGRIN2CCTSKCYP4F2CYP4A11 | |
| SCHEMBL2433746 | 0.80 | GRIN2B (0.39) | GRIN2BGRIN2CCTSKJAK3CNR2 | |
| SCHEMBL28504862 | 0.79 | JAK3 (0.36) | GRIN2BGRIN2CCTSKCYP4F2CYP4A11 | |
| SCHEMBL444153 | 0.77 | GRIN2B (0.45) | GRIN2BGRIN2CCTSKJAK3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951183-B1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2019-03-13 | — | — | EP | disclosed |