SCHEMBL2080684

SCHEMBL2080684

CC(C)c1cccnc1CNC(CCCN)Cc1ncccc1N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 6/20 0.39
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
CYP1A2 P05177 2/20 0.32
ABCB11 O95342 1/20 0.32
ESR1 P03372 1/20 0.32
PGR P06401 1/20 0.32
ADRB2 P07550 1/20 0.32
CHRM2 P08172 1/20 0.32
ADRB1 P08588 1/20 0.32
HTR1A P08908 1/20 0.32
ADRA2A P08913 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
NQO2 P16083 1/20 0.32
MAOA P21397 1/20 0.32
PTGS1 P23219 1/20 0.32
SLC6A2 P23975 1/20 0.32
MAOB P27338 1/20 0.32
PDE4A P27815 1/20 0.32
SLC6A4 P31645 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2082834 0.85 CXCR4 (0.33) CXCR4HSP90AA1HSP90AB1CYP1A2ABCB11
SCHEMBL2082216 0.83 CXCR4 (0.36) CXCR4HSP90AA1HSP90AB1
SCHEMBL2083520 0.83 CXCR4 (0.35) CXCR4HSP90AA1HSP90AB1CYP1A2ABCB11
SCHEMBL2082894 0.83 CXCR4 (0.42) CXCR4HSP90AA1HSP90AB1CYP1A2ABCB11
SCHEMBL2085865 0.82 CXCR4 (0.33) CXCR4HSP90AA1HSP90AB1CYP1A2ABCB11
SCHEMBL2084457 0.81 CXCR4 (0.35) CXCR4HSP90AA1HSP90AB1CYP1A2ABCB11
SCHEMBL2085658 0.81 CXCR4 (0.33) CXCR4HSP90AA1HSP90AB1CYP1A2ABCB11
SCHEMBL2085384 0.78 CXCR4 (0.43) CXCR4CYP1A2CHRM2OPRM1KCNH2
SCHEMBL4214955 0.78 CXCR4 (0.41) CXCR4HSP90AA1HSP90AB1CYP1A2ABCB11
SCHEMBL2084798 0.74 CXCR4 (0.52) CXCR4HSP90AA1HSP90AB1CYP1A2ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7863293-B2 CXCR4 chemokine receptor binding compounds GENZYME CORPORATION (US) 2011-01-04 US claimed
US-7863293-B2 CXCR4 chemokine receptor binding compounds GENZYME CORPORATION (US) 2011-01-04 US disclosed