Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TOP1 | P11387 | 5/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18774810 | 1.00 | HDAC3 (0.40) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL24062776 | 0.96 | HDAC3 (0.40) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL18774804 | 0.92 | TOP1 (0.47) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL20807206 | 0.92 | TOP1 (0.47) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL20807097 | 0.92 | TOP1 (0.47) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL18774813 | 0.90 | HDAC3 (0.46) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL24062828 | 0.88 | TOP1 (0.46) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL20807209 | 0.87 | TOP1 (0.47) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL2602723 | 0.86 | KDM4E (0.51) | HDAC3HDAC1HDAC6LMNACYP3A4 | |
| SCHEMBL13675189 | 0.86 | KDM4E (0.51) | HDAC3HDAC1HDAC6LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190077813-A1 | PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE | CALIFORNIA PACIFIC MEDICAL CENTER (US) | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077813-A1 | PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE | CCNT2, CCNT1, CCNY | HDAC3 1650/4885HDAC1 813/4885HDAC6 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.