Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.40 |
| ▸ | TOP1 | P11387 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HBB | P68871 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18774810 | 0.96 | HDAC3 (0.40) | HDAC3HDAC1HDAC6TOP1KDM4E | |
| SCHEMBL20807096 | 0.96 | HDAC3 (0.40) | HDAC3HDAC1HDAC6TOP1KDM4E | |
| SCHEMBL24062828 | 0.92 | TOP1 (0.46) | HDAC3HDAC1HDAC6TOP1KDM4E | |
| SCHEMBL18774804 | 0.88 | TOP1 (0.47) | HDAC3HDAC1HDAC6TOP1KDM4E | |
| SCHEMBL20807097 | 0.88 | TOP1 (0.47) | HDAC3HDAC1HDAC6TOP1KDM4E | |
| SCHEMBL20807206 | 0.88 | TOP1 (0.47) | HDAC3HDAC1HDAC6TOP1KDM4E | |
| SCHEMBL18774813 | 0.85 | HDAC3 (0.46) | HDAC3HDAC1HDAC6TOP1LMNA | |
| SCHEMBL24062777 | 0.85 | GLA (0.54) | HDAC3HDAC1HDAC6TOP1KDM4E | |
| SCHEMBL20807209 | 0.82 | TOP1 (0.47) | HDAC3HDAC1HDAC6TOP1KDM4E | |
| SCHEMBL24062788 | 0.81 | TOP1 (0.53) | TOP1KDM4ESMN1; SMN2HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186594-B2 | Podophyllotoxin derivatives and their use | CALIFORNIA PACIFIC MEDICAL CENTER (US) | 2021-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11186594-B2 | Podophyllotoxin derivatives and their use | CASP7, CASP3, PTMA | HDAC3 3016/4885HDAC1 2136/4885HDAC6 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.