Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 10/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19656691 | 0.83 | CFTR (0.47) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL23278436 | 0.83 | CFTR (0.40) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL15096108 | 0.82 | CFTR (0.43) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL14845721 | 0.82 | CFTR (0.41) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL19651573 | 0.76 | CFTR (0.62) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL15096107 | 0.72 | NR1I2 (0.43) | CFTR | |
| SCHEMBL14845720 | 0.72 | CFTR (0.42) | CFTRHTR2A | |
| SCHEMBL17793903 | 0.71 | CFTR (0.48) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL23278438 | 0.71 | CFTR (0.42) | CFTR | |
| SCHEMBL19027867 | 0.70 | CFTR (0.55) | CFTRHTR2APDE4DSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190076419-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190076419-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | CFTR 1/4885HTR2A 2929/4885PDE4D 1354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.