Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 12/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 4/20 | 0.34 |
| ▸ | SRC | P12931 | 4/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201547 | 0.81 | BTK (0.48) | NUDT1TNK2BTKABL1SRC | |
| SCHEMBL17893144 | 0.81 | NUDT1 (0.34) | NUDT1TNK2BTKABL1SRC | |
| SCHEMBL1129368 | 0.81 | NUDT1 (0.34) | NUDT1TNK2BTKABL1SRC | |
| SCHEMBL13218530 | 0.81 | TNK2 (0.37) | NUDT1TNK2BTKABL1SRC | |
| SCHEMBL12436063 | 0.78 | SRC (0.53) | NUDT1TNK2BTKABL1SRC | |
| SCHEMBL12437111 | 0.78 | TNK2 (0.51) | NUDT1TNK2BTKABL1SRC | |
| SCHEMBL1130563 | 0.78 | TNK2 (0.51) | NUDT1TNK2BTKABL1SRC | |
| SCHEMBL398874 | 0.74 | FGFR2 (0.57) | TNK2FGFR2 | |
| SCHEMBL4316054 | 0.72 | TNK2 (0.48) | TNK2FGFR2 | |
| SCHEMBL13962774 | 0.72 | TNK2 (0.56) | TNK2FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948431-B1 | BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2019-03-13 | — | — | EP | disclosed |