Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 5/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | FRK | P42685 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20813389 | 0.79 | MIF (0.68) | MIFGRM5MAP4K4HDAC8 | |
| SCHEMBL2814353 | 0.79 | HSP90AA1 (0.52) | GRM5GSK3BHSP90AA1CYP2D6MAPK14 | |
| SCHEMBL30595872 | 0.79 | HSP90AA1 (0.52) | GRM5GSK3BHSP90AA1CYP2D6MAPK14 | |
| SCHEMBL20813388 | 0.78 | MIF (0.60) | MIFGRM5HSP90AA1HDAC8 | |
| SCHEMBL16397837 | 0.75 | GRM5 (0.45) | GRM5GSK3BHSP90AA1CYP2D6MAPK14 | |
| SCHEMBL30448395 | 0.75 | HSP90AA1 (0.58) | GRM5GSK3BHSP90AA1CYP2D6MAPK14 | |
| SCHEMBL16398730 | 0.75 | GRM5 (0.50) | GRM5GSK3BHSP90AA1CYP2D6MAPK14 | |
| SCHEMBL27109835 | 0.75 | GRM5 (0.45) | GRM5GSK3BHSP90AA1CYP2D6LATS1 | |
| SCHEMBL10402322 | 0.74 | HSP90AA1 (0.48) | GRM5GSK3BHSP90AA1CYP2D6MAPK14 | |
| SCHEMBL171767 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327882-A2 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | The Board of Trustees of the Leland Stanford Junior University (US) | 2024-02-28 | — | — | EP | disclosed |
| WO-2023077083-A1 | ENPP1 INHIBITORS AS INHIBITORS OF METASTASIS | ANGARUS THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021226136-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | ANGARUS THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |
| WO-2019051269-A1 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-03-14 | — | — | WO | disclosed |