Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 11/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16447456 | 0.78 | ALDH1A1 (0.49) | PDE5AEGFRABL1PDGFRBFGFR1 | |
| SCHEMBL29589537 | 0.78 | PDE5A (0.48) | PDE5AEGFRABL1PDGFRBFGFR1 | |
| SCHEMBL8807079 | 0.78 | PDE5A (0.48) | PDE5AEGFRABL1PDGFRBFGFR1 | |
| SCHEMBL367950 | 0.78 | PDE5A (0.48) | PDE5AEGFRABL1PDGFRBFGFR1 | |
| Hydrochloric Acid SCHEMBL8808443 | 0.76 | PDE5A (0.47) | PDE5AEGFRABL1PDGFRBFGFR1 | |
| SCHEMBL24391688 | 0.74 | PDE5A (0.45) | PDE5AEGFRABL1PDGFRBFGFR1 | |
| SCHEMBL3520125 | 0.71 | CLK4 (0.62) | PDE5AEGFRABL1PDGFRBFGFR1 | |
| SCHEMBL11852402 | 0.69 | PDE5A (0.64) | PDE5AEGFRABL1PDGFRBFGFR1 | |
| SCHEMBL2913230 | 0.68 | CYP1A2 (0.71) | PDGFRBCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL20813468 | 0.68 | EGFR (0.41) | EGFRSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327882-A2 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | The Board of Trustees of the Leland Stanford Junior University (US) | 2024-02-28 | — | — | EP | disclosed |
| WO-2023077083-A1 | ENPP1 INHIBITORS AS INHIBITORS OF METASTASIS | ANGARUS THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021226136-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | ANGARUS THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |
| WO-2019051269-A1 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-03-14 | — | — | WO | disclosed |