Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.49 |
| ▸ | PDE4A | P27815 | 5/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | MGAM | O43451 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | SI | P14410 | 3/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HK2 | P52789 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56424 | 0.79 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL12639202 | 0.78 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL17038908 | 0.77 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL6130251 | 0.77 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL19664921 | 0.75 | BACE1 (0.41) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL10536048 | 0.71 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL27876715 | 0.71 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL12181771 | 0.70 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| Bromide SCHEMBL2067484 | 0.69 | BACE1 (0.45) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL20323146 | 0.69 | BACE1 (0.59) | BACE1ALDH1A1HTTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11299577-B2 | Method for the production of thermoplastic polyoxazolidinone polymers | COVESTRO DEUTSCHLAND AG (DE) | 2022-04-12 | — | — | US | disclosed |
| EP-3681923-B1 | METHOD FOR THE PRODUCTION OF THERMOPLASTIC POLYOXAZOLIDINONE POLYMERS | COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) | 2021-07-21 | — | — | EP | disclosed |
| US-20200385507-A1 | METHOD FOR THE PRODUCTION OF THERMOPLASTIC POLYOXAZOLIDINONE POLYMERS | COVESTRO DEUTSCHLAND AG (DE) | 2020-12-10 | — | — | US | disclosed |
| EP-3681923-A1 | METHOD FOR THE PRODUCTION OF THERMOPLASTIC POLYOXAZOLIDINONE POLYMERS | Covestro Deutschland AG (DE) | 2020-07-22 | — | — | EP | disclosed |
| CN-111094380-A | Process for producing thermoplastic polyoxazolidone polymers | 科思创德国股份有限公司 | 2020-05-01 | — | — | CN | disclosed |
| WO-2019052991-A1 | METHOD FOR THE PRODUCTION OF THERMOPLASTIC POLYOXAZOLIDINONE POLYMERS | COVESTRO DEUTSCHLAND AG (DE) | 2019-03-21 | — | — | WO | disclosed |
| EP-3456753-A1 | METHOD FOR THE PRODUCTION OF THERMPLASTIC POLYOXAZOLIDINONE POLYMERS | Covestro Deutschland AG (DE) | 2019-03-20 | — | — | EP | disclosed |