Puromycin

Puromycin

SCHEMBL20815730

COc1ccc(C[C@H](N)C(=O)NC2[C@@H](O)[C@H](n3cnc4c(N(C)C)ncnc43)O[C@@H]2CO)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ NPEPPS P55786 12/20 1.00
▸ ANPEP P15144 10/20 1.00
▸ SMN1; SMN2 Q16637 3/20 1.00
▸ TP53 P04637 2/20 1.00
▸ CYP3A4 P08684 2/20 1.00
▸ LMNA P02545 1/20 1.00
▸ HIF1A Q16665 1/20 1.00
▸ HTT P42858 1/20 0.99
▸ NPC1 O15118 1/20 0.99
▸ RAB9A P51151 1/20 0.99
▸ PAX8 Q06710 1/20 0.99
▸ SLC29A1 Q99808 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Puromycin SCHEMBL14583797 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL13170049 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL12799451 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22409382 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL18190282 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21306559 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL24206459 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22348910 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21481061 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL3042415 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260098255-A1 COMPOSITIONS AND METHODS FOR IDENTIFICATION OF VHH ANTIBODIES THAT BIND A TARGET ANTIGEN THE BROAD INSTITUTE, INC. (US) 2026-04-09 — — US disclosed
WO-2024259299-A1 COMPOSITIONS AND METHODS FOR IDENTIFICATION OF VHH ANTIBODIES THAT BIND A TARGET ANTIGEN THE BROAD INSTITUTE, INC. (US) 2024-12-19 — — WO disclosed
US-20200309767-A1 HIGH-THROUGHPUT IMAGING-BASED METHODS FOR PREDICTING CELL-TYPE-SPECIFIC TOXICITY OF XENOBIOTICS WITH DIVERSE CHEMICAL STRUCTURES AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2020-10-01 — — US disclosed
US-10683511-B2 Method for the fermentative production of L-amino acids EVONIK OPERATIONS GMBH (DE) 2020-06-16 — — US disclosed
EP-3456834-B1 METHOD FOR THE FERMENTATIVE PRODUCTION OF L-AMINO ACIDS EVONIK OPERATIONS GMBH (DE) 2020-02-26 — — EP disclosed
US-20190085340-A1 METHOD FOR THE FERMENTATIVE PRODUCTION OF L-AMINO ACIDS EVONIK OPERATIONS GMBH (DE) 2019-03-21 — — US disclosed
EP-3456834-A1 METHOD FOR THE FERMENTATIVE PRODUCTION OF L-AMINO ACIDS Evonik Degussa GmbH (DE) 2019-03-20 — — EP disclosed
EP-3456833-A1 METHOD FOR THE FERMENTATIVE PRODUCTION OF L-AMINO ACIDS Evonik Degussa GmbH (DE) 2019-03-20 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260098255-A1 COMPOSITIONS AND METHODS FOR IDENTIFICATION OF VHH ANTIBODIES THAT BIND A TARGET ANTIGEN CD47, BCR, MYD88 NPEPPS 1154/4885ANPEP 1415/4885SMN1; SMN2 2180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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